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This book covers knowledge of recent root canal sealers used in dentistry in a simplified manner. Properties of sealers, their effect on culture cells depicting their cytotoxicity level in a timely fashion. sealers were tested in vitro to simulate the conditions in vivo. Biological compatibility of root canal sealers is of importance as these materials frequently come into contact with periapical tissues. The tissue response to these materials may influence the final outcome of the root canal treatment. A sealer should not hinder tissue repair, but aid or stimulate the reorganization of injured structures. Various researches and studies have been done previously to test the biocompatibility of different material classes and products of root canal sealers. The results of these studies varies considerably depending upon the methods employed and other factors affecting the efficacy of test. The study, “Comparative evaluation of cytotoxicity profile of different root canal sealers : An in vitro analysis” was conducted in the Department of Conservative Dentistry and Endodontics,King George's Medical University, Lucknow in collaboration with Central Drug and Research Institute, Lucknow.


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